Tonsillar homing of Epstein-Barr virus–specific CD8+ T cells and the virus-host balance
J. Clin. Invest. Andrew D. Hislop, et al. 115:2546 doi:10.1172/JCI24810 [Go to this article.]

Figure 2
Frequency of EBV-specific CD8⁺ T cells in PBMCs and matched tonsil preparations from IM, post-IM, and long-term carrier tonsillectomy patients. (A) PBMCs (left panels) and tonsillar cells (right panels) from acute IM patient IM-5 were stained with either HLA-B*0801 tetramers containing the lytic cycle epitope RAK or latent cycle epitope QAK peptides or the HLA-A*0201 tetramer containing the lytic cycle epitope YVL peptide and subsequently stained with anti-CD8 mAbs. Values shown refer to the percentage of CD8⁺ T cells that stained with the tetramer. (B) PBMCs and tonsillar cells from post-IM-1 were stained as described above with HLA-A*0201 tetramers containing either the lytic cycle epitope YVL or GLC or the latent cycle epitope CLG peptides. (C) PBMCs and tonsillar cells from carrier-32 were stained as described above with the HLA-B*0801 tetramers containing the lytic cycle epitope RAK or latent cycle epitope FLR peptides or the HLA-A*0201 tetramer containing the lytic cycle epitope GLC peptide.