Treatment of murine Th1- and Th2-mediated inflammatory bowel disease with NF-κB decoy oligonucleotides
J. Clin. Invest. Stefan Fichtner-Feigl, et al. 115:3057 doi:10.1172/JCI24792 [Go to this article.]

Figure 8
Effect of NF-κB decoy ODNs administered via an i.r. route on NF-κB binding activity in extraintestinal mononuclear cells. TNBS-colitis was induced by i.r. instillation of TNBS in ethanol. Mice were treated with NF-κB decoy ODNs (or scrambled ODNs) via an i.r. route (4 hours) or via an i.p. route (4, 24, and 48 hours). DNA-binding activity of p65 on day 5 after TNBS administration was measured in nuclear extracts derived from colonic LPMCs, liver mononuclear cells, and splenocytes by TransFactor assay. Data shown are representative of 2 independent experiments involving at least 3 mice in each group. *P < 0.01.