Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2
J. Clin. Invest. Kush M. Parmar, et al. 116:49 doi:10.1172/JCI24787 [Go to this article.]

Figure 2
Elucidation of KLF2-regulated global gene expression programs. (A) Visualization of whole-genome expression patterns controlled by KLF2 and/or IL-1β in HUVECs. HUVECs were infected with either Ad-GFP or Ad-KLF2 and incubated for 24 hours before RNA was isolated and analyzed using whole genome microarrays. Self-organizing map software was used to cluster similarly regulated genes and colorize them based on intensity of expression relative to GFP-expressing (control) cells. (B) Selected KLF2-responsive genes grouped by clusters shown in A, with major associated biological functions listed. Dev, development.