Mapping quantitative trait loci in humans: achievements and limitations
J. Clin. Invest. Partha P. Majumder, et al. 115:1419 doi:10.1172/JCI24757 [
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Figure 1Genetic effects of a single QTL with 2 alleles. The variances of QT values within genotypes can be unequal. The differences in mean values between
AA and
Aa genotypes need not be the same as the difference in the mean values between
Aa and
aa genotypes. If the mean value of the QT for genotype
Aa is exactly in the middle of the mean values for genotypes
AA and
aa, then the 2 alleles
A and
a have additive effects. If the heterozygote mean is shifted toward the mean value of either of the homozygotes, then there is a dominance effect.
