Illuminating the role of type I IFNs in colitis
J. Clin. Invest. Stefan Wirtz, et al. 115:586 doi:10.1172/JCI24518 [Go to this article.]

Figure 1
Hypothetical model for a regulatory role of type I IFNs in the gut. Intestinal bacteria entering the mucosa after epithelial damage or exogenous administration of CpG ODNs are recognized by mucosal plasmacytoid dendritic cells (pDCs) via TLR9. Stimulated pDCs produce IFN-α/β, which promote epithelial regeneration or generation of regulatory T cell subsets (e.g., T regulatory 1 cells; Tr1).