Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice
J. Clin. Invest. Xu Peng, et al. 116:217 doi:10.1172/JCI24497 [Go to this article.]

Figure 2
Cardiac hypertrophic responses upon angiotensin II stimulation in CFKO mice. Heart and liver were harvested at 14 days after Ang II infusion (A, C, and E) or 10 days after TAC (B, D, and F), as described in Methods. Heart/body weight (Hw/Bw; mg/g) (A and B), heart weight/tibial length (Hw/Tl; mg/mm) (C and D), and liver/body weight (Lw/Bw; mg/g) (E and F) ratios of the CFKO mice and their littermate floxed (FAK^flox/flox) and Cre (FAK^flox/+MLC2vCre^KI/+) controls were determined. Heart and liver of at least 8 mice of each group were weighed, and values represent mean ± SD. *P < 0.05 compared with values from floxed and Cre controls.