Ets-1 is a critical regulator of
Ang II-mediated vascular
inflammation and remodeling
J. Clin. Invest. Yumei Zhan, et al. 115:2508 doi:10.1172/JCI24403 [
Go to this article.]
Figure 3Reduction in the recruitment of inflammatory cells in
Ets1–/– mice in response to Ang II. Immunohistochemical staining (upper panels; original magnification, ×250) and quantitative analysis (lower panels) of infiltration of CD3 (T cells) and Mac3 (macrophages) in the thoracic aorta of
Ets1+/+ versus
Ets1–/– mice after infusion of Ang II (1.4 mg/kg/d) for 1 week. Arrowheads indicate positively stained cells. *
P < 0.01 versus
Ets1+/+ mice. Values represent mean ± SEM;
n = 5.
