Distinct mechanisms of TGF-β1–mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis
J. Clin. Invest. Gangwen Han, et al. 115:1714 doi:10.1172/JCI24399 [Go to this article.]

Figure 2
Skin tumor formation and tumor types in transgenic mice. (A) Schematic of the skin chemical carcinogenesis and TGF-β₁ transgene induction protocol. (B) Kinetics of tumor formation. Each point represents the average number of tumors per mouse. (C) H&E staining of TGF-β₁/ΔβRII–transgenic SCC. (D) TGF-β₁–transgenic SPCC. (E) Metastatic lesion in lymph node showing SCC cells surrounded by lymphocytes. (F) Lung metastasis that originated from TGF-β₁/ΔβRII–transgenic SCCs. The dotted line delineates lung tissue adjacent to the metastatic lesion. Scale bar in C: 40 μm for C–F.