Distinct mechanisms of TGF-β1–mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis
J. Clin. Invest. Gangwen Han, et al. 115:1714 doi:10.1172/JCI24399 [
Go to this article.]
Figure 1Immunostaining for TGF-β
1, TGF-βRII, and pSmad2 in human skin cancer samples revealed a patchy increase in TGF-β
1 and decrease in TGF-βRII staining in AK and CIS, and the same alterations were uniform in SCC. pSmad2-positive cells were detected in AK and CIS. Scale bar: 40 μm for all panels.
