Carcinoembryonic antigen–related cell adhesion molecule 1 modulates vascular remodeling in vitro and in vivo
J. Clin. Invest. Andrea Kristina Horst, et al. 116:1596 doi:10.1172/JCI24340 [Go to this article.]

Figure 7
Electron microscopy of Matrigel implants. To analyze the underlying vascular defects in Matrigel implants from Ceacam1^–/– mice and to verify vessel integrity in CEACAM1^endo+ mice, the implants were subjected to electron microscopy. Here we chose implants that had been treated with VEGF. In specimens from CEACAM1^endo+ mice, an intact capillary consisting of an endothelial cell (EC) and a pericyte (P) as well as a basal lamina (thick arrows) was detected. Strikingly, no capillaries were present in explants from Ceacam1^–/– mice; instead, apoptotic cells (arrowheads) and extravascular red blood cells (RBC; thin arrows) were visible. In addition, poorly organized bundles of collagen (C) were scattered within the explants. Magnification, ×2,250.