CCR2 modulates inflammatory and metabolic effects of high-fat feeding
J. Clin. Invest. Stuart P. Weisberg, et al. 116:115 doi:10.1172/JCI24335 [
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Figure 7Expression of genes involved in adipocyte function. Quantitative RT-PCR was used to measure the expression in periepididymal adipose tissue of genes involved in adipocyte function (
Fabp4,
Gpam,
Lipe,
Pparg, and
Acdc). Obese
Ccr2
–/– (light gray bars) and obese
Ccr2
+/+ (dark gray bars) mice with body mass greater than 40 g were studied, as were lean
Ccr2
+/+ mice (black bars) and lean
Ccr2
–/– mice (white bars). *
P < 0.05, mice with dietary obesity compared with lean mice of the same genotype;
ΧP < 0.05, obese
Ccr2+/+ compared with obese
Ccr2–/– mice.
#NS. Values are expressed as mean ± SEM.