CCR2 modulates inflammatory and metabolic effects of high-fat feeding
J. Clin. Invest. Stuart P. Weisberg, et al. 116:115 doi:10.1172/JCI24335 [Go to this article.]

Figure 6
Expression of genes involved in inflammation. Quantitative RT-PCR was used to measure the expression in periepididymal adipose tissue of genes involved in macrophage function and inflammation (Tnfa, Cd68, Emr1, and Serpine1). Obese Ccr2–/– (light gray bars) and obese Ccr2+/+ (dark gray bars) mice with body mass greater than 40 g were studied, as were lean Ccr2+/+ mice (black bars) and lean Ccr2–/– mice (white bars). *P < 0.05, obese mice on high-fat chow compared with mice of the same genotype on low-fat chow; ^ΧP < 0.05, obese Ccr2^+/+ compared with obese Ccr2^–/– mice. Values are expressed as mean ± SEM.