CCR2 modulates inflammatory and metabolic effects of high-fat feeding
J. Clin. Invest. Stuart P. Weisberg, et al. 116:115 doi:10.1172/JCI24335 [
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Figure 5CCR2 deficiency lowers ATM content in obese mice. The fraction of F4/80-expressing macrophages was determined by immunohistochemical analysis of epididymal adipose tissue from obese
Ccr2+/+ (
A) and
Ccr2–/– (
B) mice with the macrophage-specific marker F4/80 (EMR1). (
C) The fraction of ATMs (F4/80-stained cells/total cells) in periepididymal adipose tissue of obese
Ccr2+/+ mice (white bar) was significantly greater than the fraction of ATMs in lean
Ccr2+/+ mice (black bar) (
P < 10
–4) and obese
Ccr2–/– mice (gray bar) (
P < 0.005). (
D) The average fraction of ATMs was also greater in subcutaneous adipose tissue of obese
Ccr2+/+ mice (black bar) compared with obese
Ccr2–/– mice (gray bar). Values are expressed as mean ± SD. **
P < 0.01 compared with obese
Ccr2+/+ mice.
