CCR2 modulates inflammatory and metabolic effects of high-fat feeding
J. Clin. Invest. Stuart P. Weisberg, et al. 116:115 doi:10.1172/JCI24335 [Go to this article.]

Figure 4
Glucose homeostasis in obese Ccr2^–/– and Ccr2^+/+ mice. (A) The response of fasted obese Ccr2^+/+ (black circles) and Ccr2^–/– (gray squares) mice following a single intraperitoneal injection of insulin (1.5 U/kg) was monitored by serially measuring blood glucose concentrations. The percent reduction in glucose concentration in obese Ccr2^–/– mice was significantly greater than that in obese Ccr2^+/+ mice at 75, 90, and 130 minutes (*P < 0.05). (B) Intraperitoneal injection of a bolus of glucose to fasted obese Ccr2^+/+ (black circles) and Ccr2^–/– (gray squares) mice lead to similar peak glucose concentrations but lower glucose concentrations at 45, 60, and 90 minutes. *P < 0.05 compared with wild type. Values are expressed as mean ± SD.