CCR2 modulates inflammatory and metabolic effects of high-fat feeding
J. Clin. Invest. Stuart P. Weisberg, et al. 116:115 doi:10.1172/JCI24335 [Go to this article.]

Figure 3
Insulin sensitivity in obese Ccr2^–/– and obese Ccr2^+/+ mice. Fasting plasma insulin (A) and blood glucose concentrations (B) were measured in lean Ccr2^+/+ (black bars) and Ccr2^–/– (gray bars) mice and mice of both genotypes made obese following 20 weeks of high-fat diet feeding. There were no significant genotype-dependent differences in fasting glucose or insulin concentrations in lean animals. However, fasting glucose and insulin concentrations were lower in obese Ccr2^–/– compared with obese Ccr2^+/+ mice despite similar degrees of adiposity (insulin: P < 0.005; glucose: P < 10^–4). (C) HOMA-IR values (expressed as IU-mg/dl) were significantly lower (P < 10^–4) among obese Ccr2^–/– than obese Ccr2^+/+ mice. (D) A plot of HOMA-IR values against body mass among all Ccr2^–/– (gray squares) and Ccr2^+/+ (black circles) mice reveals that the relationship between insulin sensitivity and body mass differs between mice dependent upon Ccr2 genotype. **P < 0.01 compared with wild type. Values are expressed as mean ± SD.