CCR2 modulates inflammatory and metabolic effects of high-fat feeding
J. Clin. Invest. Stuart P. Weisberg, et al. 116:115 doi:10.1172/JCI24335 [
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Figure 2Body mass of
Ccr2–/– mice.
(
A) C57BL/6J
Ccr2+/+ (black symbols) and
Ccr2–/– (gray symbols) mice were fed a low-fat (triangles) or a high-fat diet (squares) for 24 weeks. There was no significant difference in body mass between mice of each genotype on the low-fat diet (
n = 5;
P > 0.05). The mean body mass of
Ccr2–/– mice fed a high-fat diet was significantly lower than that of the
Ccr2+/+ mice (39.3 ± 6.9 g vs. 46.3 ± 4.1 g;
n = 10;
P < 0.05). (
B) Average daily food intake was measured over a 6-week period for
Ccr2+/+ and
Ccr2–/– mice fed a high-fat diet. *
P < 0.05 vs.
Ccr2+/+.
