In vivo expansion of CD4+CD45RO–CD25+
T cells expressing foxP3 in IL-2-treated
HIV-infected patients
J. Clin. Invest. Irini Sereti, et al. 115:1839 doi:10.1172/JCI24307 [
Go to this article.]
Figure 4A lower proportion of CEN cells than of naive CD4
+CD25
– cells produce IL-2. (
A) IL-2 production was studied with intracellular cytokine staining after stimulation of separated subsets with PMA and ionomycin for 4 hours (
n = 11,
P = 0.001). (
B) Separated CD45RO
– subsets showed similar degrees of activation (as measured by CD69 expression) despite significant differences in IL-2 production. (
C) CD45RO
+CD25
+high cells did not produce IL-2 after similar stimulation (
n = 6).
