In vivo expansion of CD4⁺CD45RO–CD25⁺ T cells expressing foxP3 in IL-2-treated HIV-infected patients
J. Clin. Invest. Irini Sereti, et al. 115:1839 doi:10.1172/JCI24307 [Go to this article.]

Figure 3
CEN cells in IL-2–treated patients have distinct phenotypic features compared with CD45RO^–CD25^– and memory cells and are less susceptible to apoptosis. (A) Representative overlay histograms from 1 patient (of 10 with similar findings) are shown. CD4⁺CD45RO^–CD25^– T cells are represented by solid light blue profiles, CD4⁺CD45RO^–CD25⁺ T cells by black lines, and CD4⁺CD45RO⁺CD25^+high cells by dashed red lines. (B) Annexin V and 7-AAD staining of separated CD4⁺CD45RO^–CD25⁺ and CD25^– and CD4⁺CD45RO⁺CD25^– and CD25^+high subsets from 1 representative patient (of 7). Both spontaneous and fas-mediated apoptosis were lower in CEN cells than in naive CD25^– or memory CD4 subsets.