In vivo expansion of CD4⁺CD45RO–CD25⁺ T cells expressing foxP3 in IL-2-treated HIV-infected patients
J. Clin. Invest. Irini Sereti, et al. 115:1839 doi:10.1172/JCI24307 [Go to this article.]

Figure 2
CD4⁺CD45RO^–CD25⁺ cells in IL-2–treated patients do not represent primary thymic emigrants but polyclonal CEN cells. (A) CD4⁺CD45RO^–CD25⁺ cells had a TREC content significantly lower than naive CD4⁺CD45RO^–CD25^– cells but higher than the memory cell subset. (B) Proviral DNA levels were similar in CD4⁺CD45RO^– subsets regardless of CD25 expression and consistently lower than in the memory cells (median values from 11 independent donors). (C) The TCR repertoire patterns of CD4⁺CD45RO^–CD25⁺ cells were similar to those of CD4⁺CD45RO^–CD25^– cells. Representative patterns from 3 different patients are shown.