Role of CXCR2/CXCR2 ligands in vascular remodeling during bronchiolitis obliterans syndrome
J. Clin. Invest. John A. Belperio, et al. 115:1150 doi:10.1172/JCI24233 [Go to this article.]

Figure 3
Representative photomicrographs of the immunolocalization of CXCR2 in human BOS lung tissue. BOS lung specimen immunostained for CXCR2 demonstrating immunolocalization to the vascular endothelium (A) and BOS lung specimen immunostained with control Ab (B). Magnification, ×400. (C) Representative photomicrograph of corneal vascular remodeling in response to FBOS, BOS, and TBOS BALF specimens with neutralizing anti-CXCR2 Ab compared with control Ab. Magnification, ×20. (D) BALF ELR⁺ CXC chemokines from patients with FBOS, BOS, and TBOS are biologically angiogenic as determined by HLMVEC chemotaxis. There is significantly more chemotaxis to the FBOS, BOS, and TBOS BALF compared with that from healthy transplant recipients. Neutralizing Abs to CXCR2 inhibited chemotaxis in the FBOS, BOS and TBOS groups, but had no effect on the healthy group. *P < 0.05.