Developmental control of CD8⁺ T cell–avidity maturation in autoimmune diabetes
J. Clin. Invest. Bingye Han, et al. 115:1879 doi:10.1172/JCI24219 [Go to this article.]

Figure 2
Developmental biology of 17.6α/8.3β versus 17.4α/8.3β TCRs in Tg mice. Flow cytometry of thymocytes (A–D) and splenocytes (E–H). (A and E) Representative CD4 versus CD8 dot plots. P values for thymic and splenic CD4:CD8 ratios were P < 0.0001 (for 17.4α/8.3β TCR-Tg vs. non-Tg mice) and P < 0.03 (for 17.6α/8.3β TCR-Tg vs. non-Tg mice). (B–D and F–H) Comparison of the intensity with which the different T cell subsets stain with anti–TCR-Vβ8 or anti–TCR-β mAbs or with IGRP_206–214 tetramers. Values on the panels correspond to percentage of cells contained within each quadrant (A and E) or to percentage of cells within each gate that stained (B–D and F–H; only values for the 2 Tg strains are shown in these panels for ease of comparison) (mean ± SE). **P < 0.05 vs. 17.4α/8.3β Tg mice. Representative histograms are shown. A–D and E–H represent 3–6 mice per strain.