Increased glucose tolerance and
reduced adiposity in the absence of
fasting hypoglycemia in mice with
liver-specific Gsα deficiency
J. Clin. Invest. Min Chen, et al. 115:3217 doi:10.1172/JCI24196 [
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Figure 6Food intake, energy expenditure, and activity studies. (
A) Food intake measured over 14 days in LGsKO (black bars) and control (white bars) mice (
n = 6/group). (
B) Resting and total O
2 consumption, (
C) total and ambulatory (Amb) activity levels, and (
D) resting and total RER measured over 24 hours at 22°C (left) and 30°C (right) (
n = 6/group). Time course of total O
2 consumption rate (
E), total RER (
F), and total activity(
G) over a 45-hour period (fed, hours 1–21; fasting, hours 22–45) at 22°C in LGsKO (filled triangles) and control (filled squares) mice (
n = 6/group). To the right of each graph are panels showing the mean ± SEM of each parameter during the fed and fasting periods.*
P < 0.05; **
P < 0.01. vO
2, volume of O
2 consumed.
