Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific G_sα deficiency
J. Clin. Invest. Min Chen, et al. 115:3217 doi:10.1172/JCI24196 [Go to this article.]

Figure 3
Glucose metabolism in fed and fasted LGsKO mice. (A) Blood glucose was measured at indicated times before and after glucagon administration in LGsKO (filled triangles) and control (filled squares) mice (n = 5/group). Serum glucose (B), insulin (C), and corticosterone (Cortico; D) levels in fed (left) and fasted (right) LGsKO and control mice (n = 5–7/group). (E) Urine norepinephrine (NE) and epinephrine (Epi) levels corrected for urine creatinine in overnight-fasted mice (n = 9/group). (F) Liver glycogen content in fed and 16-hour- and 24-hour-fasted mice (n = 6–7/group). *P < 0.05; **P < 0.01.