Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display
J. Clin. Invest. Aimee S. Payne, et al. 115:888 doi:10.1172/JCI24185 [Go to this article.]

Figure 5
Anti-Dsg scFv mAbs are pathogenic in neonatal mice. (A) Injection of (D3)3c/9 alone into neonatal mice does not cause gross blistering; histologic examination (lower panel) supports this result. (B) Injection of (D3)3c/9 with low-dose ETA demonstrates suprabasilar blistering. (C) Injection of (D31)2/28 alone demonstrates superficial blistering in the granular layer of the epidermis. (D) Coinjection of (D3)3c/9 and (D31)2/28 demonstrates suprabasilar blistering. Magnification, ×400.