Heme-regulated eIF2α kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and β-thalassemia
J. Clin. Invest. An-Ping Han, et al. 115:1562 doi:10.1172/JCI24141 [Go to this article.]

Figure 5
More severe pathology of β-thalassemic mice lacking 1 copy of HRI gene. (A) Complete blood cell counts in the adult mice. Data are presented as mean ± SD. Units of the hematological parameters are the same as in Figure 1. HCT, hematocrit (expressed as percentages). (B) Wright-Giemsa stained peripheral blood smears. Inclusions are indicated by arrows. Original magnification, ×1000. (C) Electron microscopic examination of inclusions in reticulocytes. Original magnification, × 22,000. (D) Splenomegaly, cardiomegaly, and iron contents in spleen and liver. Tissue irons are expressed as μg iron/g of body weight. Data are presented as mean ± SD. Twelve- to sixteen-week-old mice were used for these experiments.