Mice with a severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities
J. Clin. Invest. Angelina J. Lay, et al. 115:1552 doi:10.1172/JCI24030 [Go to this article.]

Figure 5
Detection of various prothrombotic and proinflammatory markers in plasma of female low-PC mice. Levels of plasma D-dimer (A), TAT (B), and P-Sel (expressed as mean fluorescence intensity [MFI]) (C), aPTT (D), platelet counts (E), granulocyte counts (F), and IL-6 levels (G) in unchallenged female mice. Black bars, WT; white bars, PC^–/–(PC^Tg785); gray bars, PC^–/–(PC^Tg527). wbc counts (H) and IL-6 levels (I) in PC^–/–(PC^Tg785) mice following a 3-day treatment with saline (white bars) or hirudin (gray bars). (J) Leukotriene B4 in WT (black bars) and PC^–/–(PC^Tg785) (white bars) mice. *P < 0.05 between groups.