Mice with a severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities
J. Clin. Invest. Angelina J. Lay, et al. 115:1552 doi:10.1172/JCI24030 [Go to this article.]

Figure 4
Histological analyses of various tissues from PC^–/–(PC^Tg785) mice. (A–D) Enhanced fibrin deposition in the PC^–/–(PC^Tg785) mice compared with WT littermates was found in the lung and the heart (arrowheads). (E and F) A thrombus in the hepatic vessel. (G and H) Anti-CD45 immunostaining revealed increased leukocyte infiltration into the alveolar space and the adjacent vein of the lung in low-PC mice. (I) Lymphocyte counts in BALF from mice at various ages. Black bars, WT mice; white bars, PC^–/–(PC^Tg785) mice. *P < 0.05 between genotypes.