Inflammation-induced lymphangiogenesis
in the cornea arises from
CD11b-positive macrophages
J. Clin. Invest. Kazuichi Maruyama, et al. 115:2363 doi:10.1172/JCI23874 [
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Figure 4Effect of macrophage depletion on lymphangiogenesis after suture placement. (
A and
B) Spot image analysis of lymphangiogenesis visualized by LYVE-1 staining (red) in each group. (
A) Clodoronate liposomes (treatment); (
B) PBS-containing liposomes (control). (
C) Quantification of lymphatic vessel invasion 7 days after suture placement (
n = 5). (
D) Immunofluorescence images showing CD11b (green) and LYVE-1 (red) staining 7 days after suture placement in mice treated with clodoronate liposomes or PBS-containing liposomes.*
P < 0.0005. Magnification, ×100.
