Acid sensing in renal epithelial cells
J. Clin. Invest. Stephen L. Gluck, et al. 114:1696 doi:10.1172/JCI23864 [
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Figure 1Acid-sensing pathway in renal proximal tubular cells. A drop in extracellular fluid pH induces a corresponding decrease in intracellular pH that induces activation of Pyk2, through an unidentified mechanism, by phosphorylation on tyrosine 402. Phosphorylated Pyk2 binds to the SH2 domain of c-Src, phosphorylating and activating it, producing subsequent activation of the MAPK and JNK signaling pathways and an increase in transcription of NHE3, the sodium-hydrogen exchanger of the proximal tubule brush border.
