Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans
J. Clin. Invest. Alexander S. Banks, et al. 115:2462 doi:10.1172/JCI23853 [
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Figure 3Increased insulin sensitivity in
Socs7 –/ – mice. (
A) Blood glucose (right) and plasma insulin (left) concentrations in overnight-fasted wild-type and
Socs7 –/ – mice aged at least 6 months. (
B) Prolonged hypoglycemia in
Socs7 –/ – mice following ITT and increased glucose clearance in GTT. All values are expressed as the mean ± SEM obtained from wild-type and
Socs7 –/ – mice. All tests were performed on 5- to 8-month-old mice. Filled circles, wild-type mice; open circles,
Socs7 –/ – mice. *
P < 0.05; **
P < 0.01; ***
P < 0.001 (1-tailed Student’s
t test). For ITT, results are given as a percentage of basal glucose concentration. (
C) Increased islet size and β cell mass in
Socs7 –/ – mice compared with wild-type littermates as assayed by staining with anti-insulin (upper panels) and antiglucagon antibodies (lower panels). Histogram represents the quantization of islet size performed using SPOT imaging software. Black bars, wild-type mice; white bars,
Socs7 –/ – mice. Magnification, ×10.
