Blood-brain barrier invasion by group B Streptococcus depends upon proper cell-surface anchoring of lipoteichoic acid
J. Clin. Invest. Kelly S. Doran, et al. 115:2499 doi:10.1172/JCI23829 [Go to this article.]

Figure 1
The newly identified ΔiagA gene contributes to host cell invasion. (A) Schematic representation of the GBS iagA region and the position of the Tn917 or pVE6007 insertion in original mutants, indicated by small arrows. (B and C) Interaction of WT and ΔiagA with hBMECs. (B) Invasion and total cell-associated (TCA; surface-adherent plus intracellular) bacteria. (C) Intracellular survival over time. (D) Invasion of cell lines hBMEC, A549 (lung epithelial cells), and JEG-3 (chorion epithelial cells) by WT and ΔiagA strains. *P < 0.005.