Inhibition of TNF receptor 1 internalization by adenovirus 14.7K as a novel immune escape mechanism
J. Clin. Invest. Wulf Schneider-Brachert, et al. 116:2901 doi:10.1172/JCI23771 [
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Figure 414.7K inhibits recruitment of essential components of the endocytotic machinery. Magnetic TNFR1 fractions were prepared and immunoblotted with the antibodies indicated. Protein cell extracts were used as controls (lysate). NIH 3T3 (
A) and C127 (
C) PM-14.7K cells exhibited regular recruitment of the indicated components of the TNFR1-associated endocytotic machinery, while NIH 3T3 (
B) and C127 (
D) 14.7K cells lacked Rab5 and dynamin 2.