NF-κB–inducing kinase controls
lymphocyte and osteoclast activities
in inflammatory arthritis
J. Clin. Invest. Kunihiko Aya, et al. 115:1848 doi:10.1172/JCI23763 [
Go to this article.]
Figure 4Spontaneous K/BxN arthritis.
Nik–/– mice and control littermates were bred to express both the KRN T cell receptor and H-2
g7 allele, a combination that leads to severe spontaneous arthritis in wild-type mice, apparent by 5 weeks. (
A) Total paw thickness (sum of results for all 4 paws) in
Nik+/? and
Nik–/– mice at 5 and 11 weeks of age. *
P < 0.0002 compared with
Nik+/?. (
B) Arthritic forepaw from
Nik+/+ mouse. (
C) Nonarthritic forepaw from
Nik–/– mouse. (
D) Arthritic hind paw from
Nik+/+ mouse. (
E) Nonarthritic hind paw from
Nik–/– mouse. Magnification, ×40.
