NF-κB–inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis
J. Clin. Invest. Kunihiko Aya, et al. 115:1848 doi:10.1172/JCI23763 [Go to this article.]

Figure 3
Histological evaluation of AIA. (A) PBS-injected control joint, with a relatively acellular joint space (between arrows). (B) mBSA-injected Nik+/– knee joint showing a severe inflammatory infiltrate (between arrows) that extends beyond the joint capsule, accompanied by bone erosion (cortical thinning; arrowhead). (C) mBSA-injected Nik–/– knee joint resembling control joint. (D) mBSA-injected Lt−α^–/– joint, showing severe inflammation despite a lack of lymph nodes. (E) mBSA-injected joint from Rag2–/– recipient of Nik+/+ unfractionated splenocytes showing severe arthritis. (F) mBSA-injected joint from Rag2–/– recipient of Nik–/– unfractionated splenocytes showing no arthritis. (G) mBSA-injected joint from Rag2–/– recipient of Nik–/– T cells and Nik+/+ B cells, showing no arthritis. (H) mBSA-injected joint from Rag2–/– recipient of Nik+/+ T cells and Nik–/– B cells, showing severe arthritis. Magnification in all panels, ×40.