Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates
J. Clin. Invest. Hisashi Bashuda, et al. 115:1896 doi:10.1172/JCI23743 [Go to this article.]

Figure 6
Representative pathological findings of kidney allografts in groups A and E. (A and B) Histology of the surviving allograft on POD 810 in group A. (A) There was minimal cellular infiltrate in evidence around small arteries but no tubulitis, glomerulitis, or endothelialitis (H&E stain; magnification, ×200). (B) Medium and small-sized arteries with elastic fiber stain showed intact architecture without intimal hyperplasia (Movat pentachrome stain; magnification, ×400). (C and D) Histology of the rejected allograft on POD 67 in group E. Diffuse and marked cell infiltration occurred. (C) The small arteries showed acute endothelialitis with fibrinoid necrosis (double arrow) and chronic allograft vasculopathy with intimal fibrous thickening and cell infiltration (single arrow), which indicated that severe and prolonged rejection developed in the graft (H&E stain; magnification, ×200). (D) Chronic allograft vasculopathy developed in medium- and small-sized arteries (Movat pentachrome stain; magnification, ×400).