Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates
J. Clin. Invest. Hisashi Bashuda, et al. 115:1896 doi:10.1172/JCI23743 [Go to this article.]

Figure 5
Assessment of the responses against alloantigens in tolerance-induced recipients. (A) Proliferative response of peripheral blood CD4⁺ T cells against alloantigens. Peripheral blood CD4⁺ T cells from a recipient with a long-surviving renal allograft were cocultured with irradiated donor (black bars) or third-party splenocytes (gray bars) preoperatively (Preop.) or 60 and 320 days after transplantation. After 7 days of culture, [³H]thymidine incorporation during the final 18 hours of culture was counted. Data are expressed as mean ± SD of triplicate samples. (B) Challenge with skin allografts. A long-surviving recipient was transplanted with autologous skin (host; autograft), donor skin (allograft), or third-party skin. Forty days after skin transplantation, the third-party skin was completely rejected, although both host and donor skin grafts remained intact, with no signs of rejection.