Differential impact of prostaglandin H synthase 1 knockdown on platelets and parturition
J. Clin. Invest. Ying Yu, et al. 115:986 doi:10.1172/JCI23683 [Go to this article.]

Figure 5
Protective effect against AA- and photochemical-induced thrombosis in hypomorphic PGHS1 mice. Mice were injected with AA via the tail vein (A) or with Rose Bengal via the jugular vein, followed by laser excitation at the right carotid artery (B and C). Percent survival of each group in A is indicated (*P < 0.001, as determined by Fisher’s exact test). (B) Representative Doppler flow tracings after photochemical injury in PGHS1-KO (top panel), PGHS1^Neo/Neo (middle panel), and WT (bottom panel) mice. Rose Bengal injection and clot occlusion times are marked with arrows. (C) Combined data for photochemical-induced arterial injury model. The number of mice examined is indicated in parentheses. ^#P < 0.05 vs. PGHS1-KO and PGHS1^Neo/Neo mice.