Differential impact of prostaglandin H synthase 1 knockdown on platelets and parturition
J. Clin. Invest. Ying Yu, et al. 115:986 doi:10.1172/JCI23683 [Go to this article.]

Figure 2
PGHS1 is downregulated in PGHS1^Neo/Neo mice. (A) Western blot analysis of PGHS1 in nonstimulated (top panel) and PGHS2 in LPS-stimulated (bottom panel) peritoneal macrophages. PGHS1 and PGHS2 protein expression in nonstimulated (B) and LPS-stimulated (C) macrophages, respectively. (D) PGE₂ production by nonstimulated peritoneal macrophages from PGHS1^Neo/Neo mice (4 mice/group; repeated 3 times). (E) Real-time RT-PCR for determination of PGHS1 mRNA levels in stomach and kidney tissue of PGHS1^Neo/Neo, WT, and PGHS1-KO mice (n = 8).