The IL-6–gp130–STAT3 pathway in hepatocytes triggers liver protection in T cell–mediated liver injury
J. Clin. Invest. Christian Klein, et al. 115:860 doi:10.1172/JCI23640 [Go to this article.]

Figure 6
IL-6–induced gene expression profile of wild-type, alfpCre gp130^LoxP/LoxP, alfpCre gp130^Y757F/LoxP, and alfpCre gp130^ΔSTAT/LoxP mice. Affimetrix GeneChip analysis was used to detect gene expression of IL-6–stimulated gp130^LoxP/LoxP, alfpCre gp130^LoxP/LoxP, alfpCre gp130^ΔSTAT/LoxP, and alfpCre gp130^Y757F/LoxP mice. Three animals per group were treated in parallel by i.p. injection of recombinant IL-6 (IL-6 rα) (200 μg/kg) or NaCl. Liver RNA was isolated, and gene expression was compared. Most of the examples shown are differentially regulated by gp130-STAT signaling. Glycine receptor (Glycine R) and cytochrome p450 (p450) represent examples that are regulated by gp130-ras-MAPK signaling. The change of gene expression level is marked by increasing color intensity. LBP, LPS binding protein.