The IL-6–gp130–STAT3 pathway in hepatocytes triggers liver protection in T cell–mediated liver injury
J. Clin. Invest. Christian Klein, et al. 115:860 doi:10.1172/JCI23640 [Go to this article.]

Figure 2
Cytokine secretion during Con A–induced hepatitis. Cytokine levels in the serum after Con A injection in wild-type (gp130^LoxP/LoxP) and alfpCre gp130^LoxP/LoxP mice. Three hours before Con A administration, animals were treated with NaCl (solid line) or IL-6 (200 μg/kg) (dotted line) by i.p. injection. (A and B) TNF-α levels of wild-type and alfpCre gp130^LoxP/LoxP mice. ^#P < 0.01 vs. corresponding IL-6–pretreated wild-type control group at the same time point. (C and D) IFN-γ levels of wild-type and alfpCre gp130^LoxP/LoxP mice. (E and F) IL-6 concentrations of wild-type and alfpCre gp130^LoxP/LoxP mice. ^§P < 0.001 and ^#P < 0.01 vs. corresponding IL-6–pretreated wild-type or alfpCre gp130^LoxP/LoxP mice at the same time point.