Identification of autoantibody clusters that best predict lupus disease activity using glomerular proteome arrays
J. Clin. Invest. Quan Li Zhen, et al. 115:3428 doi:10.1172/JCI23587 [Go to this article.]

Figure 5
The strongest IgG antiglomerular reactivities in human lupus sera. Sera from 11 healthy adults (NHS), 37 lupus patients (SLE) with varying degrees of disease (see Table 1), and 5 RA patients were applied to the glomerular proteome arrays as shown in Figure 1A and developed using Cy5-labeled anti-human IgG. The relative fluorescence intensities for each Ag are depicted using a green/black/red heat map and clustered Ag-wise as described in the legend to Figure 2B. Indicated on the left margin are 5 distinct groups of Ags, the reactivities to which were noted to cluster together in the tested samples. Depicted results are representative of 2 independent experiments using the same sera but fresh arrays. P values indicated at right were the result of comparing the lupus sera against the normal controls. An additional SLE column has been included which shows results from 1 duplicated sample. *P < 0.05; **P < 0.01.