TWEAK induces liver progenitor
cell proliferation
J. Clin. Invest. Aniela Jakubowski, et al. 115:2330 doi:10.1172/JCI23486 [
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Figure 7TWEAK pathway blockade in DDC-fed mice inhibits the proliferation of A6-expressing oval cells. DDC-fed mice were dosed with either hamster anti-TWEAK mAb, hamster control mAb, or PBS and sacrificed 7 days later. Frozen liver sections were stained for A6 expression. The amount of positive staining was then quantitated using MetaMorph software. (
A) Mouse fed regular diet with no DDC. (
B) DDC-fed mouse. (
C) Control Ig-treated DDC-fed mouse. (
D) Hamster anti-TWEAK mAb–treated DDC-fed mouse. Magnification, ×200. (
E) Quantitation of A6 staining using MetaMorph software. *
P < 0.05 by 2-tailed Student’s
t test.
