TWEAK induces liver progenitor
cell proliferation
J. Clin. Invest. Aniela Jakubowski, et al. 115:2330 doi:10.1172/JCI23486 [
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Figure 4Increased Fn14 mRNA expression in the hyperplastic regions of adult TWEAK-Tg relative to Ntg livers. Fn14 mRNA expression was detected by in situ hybridization using a murine Fn14 riboprobe template. (
A–
D) Ntg liver in (
A) E18.5 embryo, (
B) newborn, and (
C) 8-week-old mouse. Darkfield (top) and brightfield (bottom) views are shown. Magnification, ×250. (
D) Ntg 8-week-old liver. Magnification, ×640. (
E–
H) TWEAK-Tg liver in (
E) E18.5 embryo, (
F) newborn, and (
G) 8-week-old mouse. Darkfield (top) and brightfield (bottom) views are shown. Magnification, ×250. (
H) TWEAK-Tg 8-week-old liver. Magnification, ×640.
