TWEAK induces liver progenitor
cell proliferation
J. Clin. Invest. Aniela Jakubowski, et al. 115:2330 doi:10.1172/JCI23486 [
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Figure 3TWEAK overexpression in transgenic mice promotes early proliferation and increased turnover of oval cells with no detectable damage in the parenchyma. (
A and
B) Proliferation, as measured by PCNA staining of TWEAK-Tg and Ntg livers at the indicated ages. (
A) PCNA-positive periportal oval cells and BECs show increased proliferation in TWEAK-Tg vs. Ntg livers. (
B) PCNA-positive hepatocytes. (
C and
D) Apoptosis detected by TUNEL staining of TWEAK-Tg and Ntg livers at the indicated ages. (
C) Apoptotic periportal oval cells and BECs show increased proliferation in TWEAK-Tg vs. Ntg livers. (
D) Apoptotic hepatocytes. PCNA- or TUNEL-positive cells were counted in 20 different fields (magnification, ×200). *
P < 0.05 by 2-tailed Student’s
t test.
