TWEAK induces liver progenitor
cell proliferation
J. Clin. Invest. Aniela Jakubowski, et al. 115:2330 doi:10.1172/JCI23486 [
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Figure 2TWEAK overexpression promotes oval cell hyperplasia. (
A–
D) H&E staining of 8- to 10-week-old (
A and
B) Ntg or (
C and
D) TWEAK-Tg livers. Magnification, ×320 (
A and
C); ×500 (
B and
D). (
E–
G) A6 (red) and CD34 (green) expression in Ntg livers. (
E) A6 expression on bile duct epithelium. (
F) CD34 expression on bile duct epithelium. (
G) Coexpression of A6 and CD34. (
H–
J) TWEAK-Tg livers showing increased expression of (
H) A6 and (
I) CD34 in oval cells and bile ducts and (
J) increased coexpression of A6 and CD34. Original magnification, ×200 (
E–
J).
