TWEAK induces liver progenitor cell proliferation
J. Clin. Invest. Aniela Jakubowski, et al. 115:2330 doi:10.1172/JCI23486 [Go to this article.]

Figure 1
TWEAK transgene is expressed primarily in the livers of 2 independent transgenic lines. (A) AAT promoter directs expression of TWEAK transgene to the liver and at low levels to the kidney. Quantitative PCR using transgene-specific primers was done with cDNA pooled from 3 adult transgenic animals. Data was normalized to the levels of the GAPDH gene. (B) Time course of TWEAK and (C) Fn14 mRNA expression in TWEAK-Tg vs. Ntg mice was measured by quantitative PCR. Each time point represents the combined RNA from 3 different animals. (D) TWEAK protein expression in 2 independent transgenic founder lines as compared with that in a control littermate. TWEAK protein was detected by staining frozen liver sections with a hamster anti-TWEAK mAb.