IL-1 mediates TNF-induced osteoclastogenesis
J. Clin. Invest. Shi Wei, et al. 115:282 doi:10.1172/JCI23394 [Go to this article.]

Figure 6
IL-4 inhibits TNF- or IL-1–induced RANKL expression. VCAM-1–positive murine marrow cells or hMSCs were pretreated with IL-4 (10 ng/ml) for indicated periods, followed by exposure to vehicle (–) or (A) TNF (10 ng/ml) or (B) IL-1 (10 ng/ml) for 24 hours. RNA was extracted and analyzed by RT-PCR.