IL-1 mediates TNF-induced osteoclastogenesis
J. Clin. Invest. Shi Wei, et al. 115:282 doi:10.1172/JCI23394 [Go to this article.]

Figure 2
TNF-induced RANKL gene expression is mediated by IL-1. (A and C) VCAM-1–positive WT or IL-1RI–deficient (IL-1RI KO) murine marrow cells or (B) hMSCs were exposed to designated cytokines or 1,25-dihydroxyvitamin D (10^–8 M) for 24 hours. In some circumstances TNF was added conjointly with IL-1Ra. RNA was extracted and subjected to RT-PCR. Numbers in parentheses represent concentrations in ng/ml.