IL-1 mediates TNF-induced osteoclastogenesis
J. Clin. Invest. Shi Wei, et al. 115:282 doi:10.1172/JCI23394 [Go to this article.]

Figure 10
IL-1 directly induces osteoclast precursor differentiation. (A) WT or p55/p75 TNF receptor–deficient (TNFR KO) murine marrow macrophages were cultured in human recombinant M-CSF (50 ng/ml) without or with RANKL and/or IL-1 at the indicated concentrations (ng/ml) at the initiation of culture. TRAP stain was performed on day 5. (B) Number of osteoclasts in cultures illustrated in panel A (* P < 0.05, ** P < 0.01, ^#P < 0.001 vs. no addition).