Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation
J. Clin. Invest. Xueliang Du, et al. 116:1071 doi:10.1172/JCI23354 [Go to this article.]

Figure 4
Effect of FFA-induced ROS production on GAPDH activity, PKC activity, and hexosamine pathway activity. Cells were incubated in 5 mM glucose alone or in 5 mM glucose plus either oleic acid alone or oleic acid plus TDGA or adenoviral vectors expressing UCP-1 or MnSOD. (A) GAPDH activity. (B) PKC activity. (C) Immunoreactive protein-bound N-acetylglucosamine (GlcNAc). Each bar represents the mean plus SEM of 3 separate experiments, each with n = 3. *P < 0.01 compared with cells incubated in 5 mM glucose alone.